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KMID : 0613820120220101415
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Journal of Life Science
2012 Volume.22 No. 10 p.1415 ~ p.1419
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Analysis of Expression Patterns of Thymosin β4 and CD133 in Normal Stomach
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Ock Mee-Sun
Cha Hee-Jae
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Abstract
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Thymosin β₄ (Tβ₄) has been reported to be overexpressed in CD133-positive colorectal cancer stem cells. We analyzed the relationship between Tβ₄ and CD133-positive stem cells in normal stomach by examining the expression patterns of Tβ₄ and CD133 in normal stomach tissues by immunohistochemical staining; co-localization of Tβ₄ and CD133 was studied by immunofluorescence and confocal laser-scanning microscopy. Both Tβ₄ and CD133 were expressed in stomach glands and showed similar expression patterns. Immunofluorescence staining of Tβ₄ and CD133 showed that the expression of Tβ₄ and CD133 was co-localized. In summary, both Tβ₄ and CD133 were expressed in glands of normal stomachs and expression patterns were co-localized. These data suggest that Tβ₄ expression is strongly related to CD133 expression.
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KEYWORD
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CD133, stem cell, stomach, thymosin β₄
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